Publications & Research

Research Areas

LCSS Development & ValidationFoundational studies establishing the conceptual framework, reliability, validity and normative data.

LCSS Psychometric & Methodologic ResearchMeasurement properties, scoring formats, longitudinal assessment and methodology.

LCSS-MesoDevelopment, validation and subsequent research involving the mesothelioma-specific adaptation.

LCSS Clinical ResearchClinical trials and observational studies in which LCSS outcomes were collected and analyzed.

Reviews & Comparative ResearchReviews and methodological publications placing the LCSS within the broader PRO literature.

Bibliography

Use the search field and category filter to narrow the bibliography. Click a column heading to sort. The default order is chronological.

Year ↕	Publication ↕	Journal ↕	Links	Research area ↕
1993	Quality of life assessment in individuals with lung cancer: testing the Lung Cancer Symptom Scale (LCSS) Hollen PJ; Gralla RJ; Kris MG; Potanovich LM	European Journal of Cancer	DOI · PubMed · Full text	LCSS Development & Validation
1994	Measurement of quality of life in patients with lung cancer in multicenter trials of new therapies: Psychometric assessment of the Lung Cancer Symptom Scale Hollen PJ; Gralla RJ; Kris MG; Cox C; Belani CP; Grunberg SM; Crawford J; Neidhart JA	Cancer	DOI · PubMed · Full text	LCSS Development & Validation
1994	Quality of life during clinical trials: conceptual model for the Lung Cancer Symptom Scale (LCSS) Hollen PJ; Gralla RJ; Kris MG; Cox C	Supportive Care in Cancer	DOI · PubMed	LCSS Development & Validation
1996	Comparison of instruments for measuring quality of life in patients with lung cancer Hollen PJ; Gralla RJ	Seminars in Oncology	PubMed	LCSS Psychometric & Methodologic Research
1997	A dilemma in analysis: issues in the serial measurement of quality of life in patients with advanced lung cancer Hollen PJ; Gralla RJ; Cox C; Eberly SW; Kris MG	Lung Cancer	DOI · PubMed · Full text	LCSS Psychometric & Methodologic Research
1999	Normative data and trends in quality of life from the Lung Cancer Symptom Scale (LCSS) Hollen PJ; Gralla RJ; Kris MG; Eberly SW; Cox C	Supportive Care in Cancer	DOI · PubMed	LCSS Development & Validation
2001	Symptom frequency and severity in patients with metastatic or locally recurrent lung cancer: a prospective study using the Lung Cancer Symptom Scale in a community hospital Lutz S; Norrell R; Bertucio C; Kachnic L; Johnson C; Arthur D; Schwarz M; Palardy G	Journal of Palliative Medicine	DOI · PubMed	LCSS Clinical Research
2004	Adapting the Lung Cancer Symptom Scale (LCSS) to mesothelioma: using the LCSS-Meso conceptual model for validation Hollen PJ; Gralla RJ; Liepa AM; Symanowski JT; Rusthoven JJ	Cancer	DOI · PubMed · Full text	LCSS-Meso
2004	Quality of life as a clinical trial endpoint: determining the appropriate interval for repeated assessments in patients with advanced lung cancer Hollen PJ; Gralla RJ; Rittenberg CN	Supportive Care in Cancer	DOI · PubMed	LCSS Psychometric & Methodologic Research
2004	Quality of life in 650 lung cancer survivors 6 months to 4 years after diagnosis Svobodnik A; Yang P; Novotny PJ; Bass E; Garces YI; Jett JR; Bonner JA; Sloan JA	Mayo Clinic Proceedings	DOI · PubMed	LCSS Clinical Research
2005	A comparison of visual analogue and numerical rating scale formats for the Lung Cancer Symptom Scale (LCSS): Does format affect patient ratings of symptoms and quality of life? Hollen PJ; Gralla RJ; Kris MG; McCoy S; Donaldson GW; Moinpour CM	Quality of Life Research	DOI · PubMed · Full text	LCSS Psychometric & Methodologic Research
2005	Lung cancer symptoms and pulse oximetry in the prognostic assessment of patients with lung cancer Martins SJ; Ho N; Cavamura SO; Harada CM; Yamamoto CA; Takagaki TY	BMC Cancer	DOI · PubMed · Full text	LCSS Clinical Research
2006	Effect of chemotherapy for advanced non-small cell lung cancer on patients' quality of life. A randomized controlled trial Belani CP; Pereira JR; von Pawel J; et al.	Lung Cancer	DOI · PubMed	LCSS Clinical Research
2006	Measuring quality of life in patients with pleural mesothelioma using a modified version of the Lung Cancer Symptom Scale (LCSS): psychometric properties of the LCSS-Meso Hollen PJ; Gralla RJ; Liepa AM; Symanowski JT; Rusthoven JJ	Supportive Care in Cancer	DOI · PubMed	LCSS-Meso
2008	Lung Cancer Symptom Scale outcomes in relation to standard efficacy measures: an analysis of the phase III study of pemetrexed versus docetaxel in advanced non-small cell lung cancer de Marinis F; Pereira JR; Fossella F; et al.	Journal of Thoracic Oncology	DOI · PubMed	LCSS Clinical Research
2009	A psychometric analysis of quality of life tools in lung cancer patients who smoke Browning KK; Ferketich AK; Otterson GA; Reynolds NR; Wewers ME	Lung Cancer	DOI · PubMed · Full text	LCSS Psychometric & Methodologic Research
2009	Assessing quality of life following neoadjuvant therapy for early stage non-small cell lung cancer (NSCLC): results from a prospective analysis using the Lung Cancer Symptom Scale (LCSS) Gralla RJ; Edelman MJ; Detterbeck FC; et al.	Supportive Care in Cancer	DOI · PubMed	LCSS Clinical Research
2011	Measuring the Symptom Burden of Lung Cancer: The Validity and Utility of the Lung Cancer Module of the M. D. Anderson Symptom Inventory Mendoza TR; Wang XS; Lu C; et al.	The Oncologist	DOI · PubMed · Full text	Reviews & Comparative Research
2012	Quality of life and symptom burden among long-term lung cancer survivors Yang P; Cheville AL; Wampfler JA; et al.	Journal of Thoracic Oncology	DOI · PubMed · Full text	LCSS Clinical Research
2013	Can a computerized format replace a paper form in PRO and HRQL evaluation? Psychometric testing of the computer-assisted LCSS instrument (eLCSS-QL) Hollen PJ; Gralla RJ; Stewart JA; Meharchand JM; Wierzbicki R; Leighl N	Supportive Care in Cancer	DOI · PubMed	LCSS Psychometric & Methodologic Research
2013	Symptom burden and quality of life in advanced non-small cell lung cancer patients in France and Germany Iyer S; Taylor-Stokes G; Roughley A	Lung Cancer	DOI · PubMed	LCSS Clinical Research
2014	The symptom burden of non-small cell lung cancer in the USA: a real-world cross-sectional study Iyer S; Roughley A; Rider A; Taylor-Stokes G	Supportive Care in Cancer	DOI · PubMed	LCSS Clinical Research
2016	Quality of life results from the phase 3 REVEL randomized clinical trial of ramucirumab-plus-docetaxel versus placebo-plus-docetaxel in advanced/metastatic non-small cell lung cancer patients with progression after platinum-based chemotherapy Pérol M; Ciuleanu TE; Arrieta O; et al.	Lung Cancer	DOI · PubMed	LCSS Clinical Research
2016	Survival Prediction in Ambulatory Patients With Stage III/IV Non-Small Cell Lung Cancer Using the Palliative Performance Scale, ECOG, and Lung Cancer Symptom Scale O'Mahony S; Nathan S; Mohajer R; et al.	American Journal of Hospice & Palliative Medicine	DOI · PubMed	LCSS Clinical Research
2016	The Effect of Necitumumab in Combination with Gemcitabine plus Cisplatin on Tolerability and on Quality of Life: Results from the Phase 3 SQUIRE Trial Reck M; Socinski MA; Luft A; et al.	Journal of Thoracic Oncology	DOI · PubMed	LCSS Clinical Research
2017	Dynamic change of fatigue of pemetrexed maintenance treatment in the JMEN trial Reck M; et al.	Lung Cancer	DOI · PubMed	LCSS Clinical Research
2018	Content validity and electronic PRO (ePRO) usability of the Lung Cancer Symptom Scale-Mesothelioma (LCSS-Meso) in mesothelioma patients Gelhorn HL; Skalicky AM; Balantac Z; et al.	Supportive Care in Cancer	DOI · PubMed	LCSS-Meso
2018	Evaluation of health-related quality of life and symptoms in patients with advanced non-squamous non-small cell lung cancer treated with nivolumab or docetaxel in CheckMate 057 Reck M; Brahmer J; Bennett B; et al.	European Journal of Cancer	DOI · PubMed	LCSS Clinical Research
2018	Impact of Nivolumab versus Docetaxel on Health-Related Quality of Life and Symptoms in Patients with Advanced Squamous Non-Small Cell Lung Cancer: Results from the CheckMate 017 Study Reck M; et al.	Journal of Thoracic Oncology	DOI · PubMed	LCSS Clinical Research
2019	Health-Related Quality of Life in Advanced Non-small Cell Lung Cancer: A Methodological Appraisal Based on a Systematic Literature Review Van der Weijst L; Lievens Y; Schrauwen W; Surmont V	Frontiers in Oncology	DOI · Full text	Reviews & Comparative Research
2019	Nivolumab plus ipilimumab versus chemotherapy as first-line treatment in advanced non-small-cell lung cancer with high tumour mutational burden: patient-reported outcomes results from the randomised, open-label, phase III CheckMate 227 trial Reck M; et al.	European Journal of Cancer	PubMed	LCSS Clinical Research
2020	A randomized trial of the electronic Lung Cancer Symptom Scale for quality-of-life assessment in patients with advanced non-small-cell lung cancer Kuo JC; Graham DM; Salvarrey A; et al.	Current Oncology	DOI · PubMed · Full text	LCSS Clinical Research
2020	Patient-reported outcomes in RELAY, a phase 3 trial of ramucirumab plus erlotinib versus placebo plus erlotinib in untreated EGFR-mutated metastatic non-small-cell lung cancer Reck M; et al.	Cancer	PubMed	LCSS Clinical Research
2021	Do Patients Regret Having Received Systemic Treatment for Advanced Non-Small Cell Lung Cancer: A Prospective Evaluation Hollen PJ; Gralla RJ; Gentzler RD; et al.	The Oncologist	DOI · PubMed · Full text	LCSS Clinical Research
2021	Non–Small Cell Lung Cancer Symptom Assessment Questionnaire: Psychometric Performance and Regulatory Qualification of a Novel Patient-Reported Symptom Measure Bushnell DM; Atkinson TM; McCarrier KP; et al.	Current Therapeutic Research, Clinical and Experimental	DOI · PubMed · Full text	Reviews & Comparative Research
2022	A Pilot Mixed-Methods Study of Malignant Pleural Mesothelioma Symptoms Walker SL; Dickson VV; Cacchione PZ	Oncology Nursing Forum	DOI · PubMed	LCSS-Meso
2022	Malignant pleural mesothelioma: treatment patterns and humanistic burden of disease in Europe Moore A; Bennett B; Taylor-Stokes G; et al.	BMC Cancer	DOI · PubMed · Full text	LCSS-Meso
2023	BRACHY: A Randomized Trial to Evaluate Symptom Improvement in Advanced Non-Small Cell Lung Cancer Treated With External Beam Radiation With or Without High-Dose-Rate Intraluminal Brachytherapy Sur S; Pond G; Falkson C; et al.	International Journal of Radiation Oncology, Biology, Physics	DOI · PubMed	LCSS Clinical Research
2024	Developing a fit-for-purpose composite symptom score as a symptom burden endpoint for clinical trials in patients with malignant pleural mesothelioma Cleeland CS; Keating KN; Cuffel B; et al.	Scientific Reports	DOI · PubMed · Full text	LCSS-Meso
2025	Treatment patterns and humanistic burden of malignant pleural mesothelioma in Spain Cedres S; Calvete J; Taylor-Stokes G; et al.	Clinical and Translational Oncology	DOI · PubMed · Full text	LCSS-Meso
1997	A retrospective quality of life analysis using the Lung Cancer Symptom Scale in patients treated with palliative radiotherapy for advanced nonsmall cell lung cancer. Lutz ST; Huang DT; Ferguson CL; Kavanagh BD; Tercilla OF; Lu J	International Journal of Radiation Oncology, Biology, Physics	DOI · PubMed	LCSS Clinical Research
2004	Quality of life assessment of second-line docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy: results of a prospective, randomized phase III trial Dancey J; Shepherd FA; Gralla RJ; Kim YS	Lung Cancer	DOI · PubMed	LCSS Clinical Research
2004	The relationship between cigarette smoking and quality of life after lung cancer diagnosis Garces YI; Yang P; Parkinson J; Zhao X; Wampfler JA; Ebbert JO; Sloan JA	Chest	DOI · PubMed	LCSS Clinical Research
2000	Clinical vs. statistical significance: Using the LCSS quality of life instrument and Karnofsky performance status (KPS) to approach the problem in patients with non-small cell lung cancer Hollen PJ; Gralla RJ	Proc Am Soc Clin Oncol. 19 (Abstract 2510)	Conference abstract	LCSS Psychometric & Methodologic Research

About This Bibliography

This page is designed as a research-facing bibliography rather than a claim of exhaustive citation coverage. Publications are grouped by their principal relationship to the LCSS and presented chronologically by default.